Premature rupture of membranes in the second trimester of pregnancy (literature review)




premature rupture of membranes, miscarriage, threatened miscarriage, premature birth


The article presents data from a literature review on the problem of premature rupture of membranes in the second trimester of pregnancy, as well as a modern scientific view of this problem. Spontaneous rupture of membranes during the second trimester presents difficult medical and ethical questions for the patient and physician. The management options of such patients range from expectant or conservative and aggressive intervention depending upon gestational age, clinical evidence of infection and maternal and fetal condition. Such pregnancies are at high risk for preterm birth, chorioamnionitis, and neonatal complications. PPROM is an important contributor to perinatal mortality and morbidity; in pregnancies that continue following PPROM at early gestations, morbidity is high among surviving neonates with problems including respiratory distress syndrome, pulmonary hypoplasia, intraventricular haemorrhage and limb contractures.
No conflict of interest were declared by the authors.


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