Evaluation of the level of reduced proteins and their recipers in the blood syrobal in children with bronchial asthma, depending on indicators of the external respiratory function

Abstract

Purpose — evaluate the level of iron-containing proteins and their receptors in blood serum of children with bronchial asthma, depending on the indicator of the function of external respiration.
Patients and methods. In accordance with the goal, we examined 227 children aged 6 to 17 years old with bronchial asthma. The total number of iron in serum, total iron binding capacity, latent iron binding ability, saturation coefficient of transferrin, level of ferritin, content of soluble receptors to transferrin (sTfR), sTfR/log index Ferritin (>1.5 — latent iron deficiency). The function of external respiration (FEV1) investigated by spirography on the Spirolab III.
Results. The conducted study determined that microcytosis in children with asthma, with severe degree of airway obstruction, was 53.76% more frequent than in patients with normal cytosis. According to our data, the indicators of ferrokinetics in the examined children with asthma depended on the degree of obstruction of the respiratory tract. Thus, in the group of children with an FEV1 index of >80%, the saturation rate of transferrin by iron was 10.4% lower; in the group of children with an indicator of FEV1 65–80% by 18.48% lower; in the group of children with FEV1 50–65% by 24.79% lower and in the group with FEV1 less than 50%, the saturation rate of transferrin by iron was 28.59% lower in relation to healthy children.
Conclusions. In children with asthma, with severe and moderate degrees of airway obstruction (according to the FEV1), iron deficiency was found to be 10.1 and 5.02 times higher than in patients with an FEV1 of 80% or more. Among the indices of iron metabolism, the most significant changes were the change in the saturation coefficient of transferrin by iron, which confirms the presence of a significant positive correlation between the coefficient of saturation of transferrin by iron and FEV1 (rxy=0.621 (p=0.026)) and moderate association with PEF (rxy=0.422 (P=0.033)). There is also a positive correlation between levels of ferritin and the value of FEV1 (rxy=0.258 (p=0.024)).
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee (LEC) participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest were declared by the authors.