Features of sensitization and clinical course of atopic dermatitis in children during the war in Ukraine
DOI:
https://doi.org/10.15574/PP.2026.1(105).510Keywords:
children, atopic dermatitis, sensitization, war, UkraineAbstract
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, which affects 15% to 20% of children and 5% to 20% of adolescents. One of the key factors influencing the clinical course of AD and the further prognosis of the disease in children is sensitization to allergens, which can be specific trigger factors. War conditions impose significant additional risks regarding the development of sensitization and the severity of the disease.
Aim - to investigate the features of the clinical course and sensitization profile in children with AD during the war in Ukraine.
Materials and methods. A retrospective analysis of medical records of 62 children aged 5-17 years with a diagnosis of AD was conducted. Children were divided into two groups: before the war (group I, n=30), and after its onset (group II, n=32). The following parameters were analyzed: gender, age, severity of AD, sensitization profile, presence of concomitant diseases.
Results. Among the patients in group II, a significant decrease in the number of children with mild AD was observed, along with a tendency toward an increase in patients with moderate-severe disease (20.0% versus 40.62%). Furthermore, concomitant bronchial asthma was significantly more prevalent in this group (20.0% versus 52.0%). Sensitization to common allergens was determined in both groups with a tendency to an increase in sensitization to «internal» aeroallergens (house dust mites and mold) in children of group II, which was associated with the established unsatisfactory condition of bomb shelters.
Conclusions. The results indicate a deterioration in the course of AD in children during the war in Ukraine, an increase in cases of AD with concomitant asthma, an increase in the frequency of sensitization to aeroallergens of the «indoor environment», which may be associated with the unsatisfactory condition of bomb shelters. The obtained data indicate the need for further scientific research on the study of risk factors associated with the war in Ukraine.
The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the patients was obtained for the research.
The authors declare no conflict of interest.
References
Adeyanju GC, Schrage P, Jalo RI, Abreu L et al. (2025). Armed violent conflict and healthcare-seeking behavior for maternal and child health in sub-Saharan Africa: A systematic review. PLoS One. 20(2): e0317094. https://doi.org/10.1371/journal.pone.0317094; PMid:39903770 PMCid:PMC11793768
Akhtar S, Alsayed RKME, Ahmad F, Al Hammadi A et al. (2024). Epigenetic control of inflammation in Atopic Dermatitis. Semin Cell Dev Biol. 154; Pt C: 199-207. https://doi.org/10.1016/j.semcdb.2023.04.005; PMid:37120405
Anania C, Brindisi G, Martinelli I, Bonucci E et al. (2022). Probiotics Function in Preventing Atopic Dermatitis in Children. Int J Mol Sci. 23(10): 5409. https://doi.org/10.3390/ijms23105409; PMid:35628229 PMCid:PMC9141149
Bantz SK, Zhu Z, Zheng T. (2014). The atopic march: Progression from atopic dermatitis to allergic rhinitis and asthma. J Clin Cell Immunol. 5(2): 202. https://doi.org/10.4172/2155-9899.1000202; PMid:25419479 PMCid:PMC4240310
Bumbacea RS, Corcea SL, Ali S, Dinica LC et al. (2020). Mite allergy and atopic dermatitis: Is there a clear link? (Review). Exp Ther Med. 20(4): 3554-3560. Epub 2020 Aug 13. https://doi.org/10.3892/etm.2020.9120; PMid:32905207 PMCid:PMC7465295
Buratynska АА, Umanets TR. (2024). Allergic diseases in children: modern condition of the problem. Ukrainian Journal of Perinatology and Pediatrics. 1(97): 84-90. https://doi.org/10.15574/PP.2024.97.84
Butuci M, Benet Z, Wong A et al. (2022). Mast cells are locally activated and respond to MRGPRX2 stimulation in atopic dermatitis ex vivo skin biopsies. J Allergy Clin Immunol. 149(2): AB5-AB5. https://doi.org/10.1016/j.jaci.2021.12.058
Cansever M, Oruç Ç. (2021). What plays a role in the severity of atopic dermatitis in children? Turk J Med Sci. 51(5): 2494-2501. https://doi.org/10.3906/sag-2101-194; PMid:34165272 PMCid:PMC8742478
Chong AC, Chwa WJ, Ong PY. (2022). Aeroallergens in atopic dermatitis and chronic urticaria. Curr Allergy Asthma Rep. 22: 67-75. https://doi.org/10.1007/s11882-022-01033-2; PMid:35362938
Dzisiak VO, Umanets TR, Antypkin YuG. (2024). Characteristics of bronchial asthma in children during the war in Ukraine. Modern Pediatrics. Ukraine. 8(144): 19-23. https://doi.org/10.15574/SP.2024.8(144).1923
Fishbein AB, Silverberg JI, Wilson EJ, Ong PY. (2020). Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection. J Allergy Clin Immunol Pract. 8(1): 91-101. https://doi.org/10.1016/j.jaip.2019.06.044; PMid:31474543 PMCid:PMC7395647
Ha EK, Kim JH, Lee SW, Jee HM et al. (2020). Atopic dermatitis: Correlation of severity with allergic sensitization and eosinophilia. Allergy Asthma Proc. 41(6): 428-435. https://doi.org/10.2500/aap.2020.41.200067; PMid:33109308
Hurraß J, Heinzow B, Walser-Reichenbach S, Aurbach U et al. (2024). AWMF mold guideline "Medical clinical diagnostics for indoor mold exposure" - Update 2023 AWMF Register No. 161/001. Allergol Select. 8: 90-198. https://doi.org/10.5414/ALX02444E; PMid:38756207 PMCid:PMC11097193
Kadir A, Shenoda S, Goldhagen J. (2019). Effects of armed conflict on child health and development: A systematic review. PLoS One. 14(1): e0210071. doi: 10.1371/journal.pone.0210071. Erratum in: PLoS One. 2019 Feb 11; 14(2): e0212393. https://doi.org/10.1371/journal.pone.0212393; PMid:30742672 PMCid:PMC6370225
Kutlu A, Karabacak E, Aydin E et al. (2013). Relationship between skin prick and atopic patch test reactivity to aeroallergens and disease severity in children with atopic dermatitis. Allergol Immunopathol. 41(6): 369-373. https://doi.org/10.1016/j.aller.2013.02.007; PMid:24094443
Ministry of Health of Ukraine. (2016). Atopic Dermatitis. Unified clinical protocol of primary, secondary (specialized), tertiary (highly specialized) medical care. Order of the Ministry of Health of Ukraine of July 4, 2016, No. 670.
Napolitano M, Fabbrocini G, Martora F, Genco L et al. (2022). Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication. Dermatol Ther. 35(12): e15901. https://doi.org/10.1111/dth.15901
Serhan N, Basso L, Sibilano R et al. (2019). House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nat Immunol. 20(11): 1435-1443. Epub 2019 Oct 7. https://doi.org/10.1038/s41590-019-0493-z; PMid:31591569 PMCid:PMC6858877
Tiplica G-S, Salavastru CM, Szepietowski JC, Czarnecka-Operacz M et al. (2019). Recommended strategies for atopic dermatitis management in Romania. Ro Med J. 66(4): 335-341. https://doi.org/10.37897/RMJ.2019.4.8
Wassmann-Otto A, Heratizadeh A, Wichmann K, Werfel T. (2018). Birch pollen-related foods can cause late eczematous reactions in patients with atopic dermatitis. Allergy. 73(10): 2046-2054. https://doi.org/10.1111/all.13454; PMid:29654628
Werfel T, Allam JP, Biedermann T, Eyerich K et al. (2016). Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol. 138: 336-349. https://doi.org/10.1016/j.jaci.2016.06.010; PMid:27497276
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