Population-based model for implementing personalized medicine in pediatric practice within a capable healthcare network
DOI:
https://doi.org/10.15574/PP.2025.4(104).5059Keywords:
personalized medicine, genetic predictors, pediatrics, healthcare organization, population-based preventionAbstract
Aim - to develop and scientifically substantiate a population-based model for the implementation of personalized medicine in pediatric practice within a capable healthcare facility network.
Materials and methods. An organizational and analytical study was conducted using a systemic analysis of the regulatory framework governing the formation of a capable healthcare network, a comparative analysis of international experience in integrating genomic medicine, and structural modeling. A multilevel model for the integration of genetic predictors into pediatric practice was developed.
Results. A three-tier organizational model (primary, cluster, and supercluster levels) was established to ensure the phased integration of genetic predictors into pediatric healthcare delivery. A population-based algorithm for family genetic support was developed, covering the continuum from the preconception period to the postnatal stage. The model incorporates risk stratification, the development of individualized preventive care pathways, and the establishment of regional registries.
Conclusions. The proposed model enables the systematic integration of personalized approaches into pediatric care, facilitates the early identification of genetic risks, and provides a foundation for reducing long-term morbidity and optimizing healthcare resources.
The author declares no conflict of interest.
References
Berm EJ, Looff MD, Wilffert B, Boersma C, Annemans L, Vegter S et al. (2016). Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening Tests: A Systematic Review. Second Update of the Literature. PloS one. 11(1): e0146262. https://doi.org/10.1371/journal.pone.0146262; PMid:26752539 PMCid:PMC4709231
Chen S, Xu H, Guo C, Liu Z, Han X. (2022). Editorial: The role of multi- omics variants in tumor immunity and immunotherapy. Frontiers in Immunology. 13. https://doi.org/10.3389/fimmu.2022.1098825; PMid:36524118 PMCid:PMC9745164
Chong HY, Allotey PA, Chaiyakunapruk N. (2018, Oct 26). Current landscape of personalized medicine adoption and implementation in Southeast Asia. BMC Med Genomics. 11(1): 94. https://doi.org/10.1186/s12920-018-0420-4; PMid:30367635 PMCid:PMC6203971
Chumnumwat S, Lu ZH, Sukasem Ch, Winther MD, Capule FR et al. (2019). Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Statusand Perspectives. Public Health Genomics. 22(3-4): 132-139. https://doi.org/10.1159/000502916; PMid:31587001
ICPerMed. (2022). ICPerMed 'Family'-Related Initiatives and ERA-Nets. URL: https://www.icpermed.eu/icpermed/icpermed-family/.
Kabinet Ministriv Ukrainy. (2023). Deiaki pytannia orhanizatsii spromozhnoi merezhi zakladiv okhorony zdorov'ia. Postanova Kabinetu Ministriv Ukrainy vid 28 liutoho 2023 r. No. 174. URL: https://zakon.rada.gov.ua/laws/show/174-2023-%D0%BF#Text.
Kabinet Ministriv Ukrainy.. (2025). Stratehiia rozvytku systemy okhorony zdorov'ia na period do 2030 roku. URL: https://zakon.rada.gov.ua/laws/show/34-2025-%D1%80#Text.
MOZ Ukrainy. (2024). Spromozhna merezha medzakladiv. URL: https://moz.gov.ua/uk/spromozhna-merezha.
Norden.Diva-Portal. (2019, Aug). Personalised Medicine in the Nordic Countries. Genome Denmark. URL: https://norden.diva-portal.org/smash/get/diva2:1347257/FULLTEXT01.pdf.
Phillips KA, Ladabaum U, Pletcher MJ, Marshall DA, Douglas MP. (2015). Key emerging themes for assessing the cost-effectiveness of reporting incidental findings. Genetics in medicine: official journal of the American College of Medical Genetics. 17(4): 314-315. https://doi.org/10.1038/gim.2015.13; PMid:25835195 PMCid:PMC4395812
Pritchard D, Hulick PJ, Wells CJ. (2021). The integration of personalized medicine into health systems: progress and a pathforward Daryl Pritchard, 1, URL: https://www.tandfonline.com/doi/epdf/10.2217/pme-2021-0102?needAccess=true. https://doi.org/10.2217/pme-2021-0102; PMid:34672204
Shah AS, Ongtengco A, Qiao V, Chen Y, Diaz A, Hill M et al. (2024). Association Between Family History and Early‐Onset Atrial Flutter Across Racial and Ethnic Groups. Journal of the American Heart Association. https://doi.org/10.1161/JAHA.123.032320; PMid:38726902 PMCid:PMC11179838
Stefanicka-Wojtas D, Kurpas D. (2023). Personalised Medicine - Implementation to the Healthcare System in Europe (Focus Group Discussions). Journal of Personalized Medicine. 13(3): 380. https://doi.org/10.3390/jpm13030380; PMid:36983562 PMCid:PMC10058568
Turova LO, Vezhnovets TA. (2024). Analiz kadrovoho zabezpechennia medyko-henetychnoi sluzhby v Ukraini. Klinichna ta profilaktychna medytsyna. (6): 117-125. https://doi.org/10.31612/2616-4868.6.2024.15
VR Ukrainy. (2022). Pro vnesennia zmin do deiakykh zakonodavchykh aktiv Ukrainy shchodo udoskonalennia nadannia medychnoi dopomohy. Zakon Ukrainy vid 1 lypnia 2022 roku No. 2347-IX. URL: https://zakon.rada.gov.ua/laws/show/2347-20#Text.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ukrainian Journal of Perinatology and Pediatrics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal “Ukrainian Journal of Perinatology and Pediatrics” is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license(СС BY-NC).
Authors transfer the copyright to the Journal “MODERN PEDIATRICS. UKRAINE” when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.
