Clinical, laboratory and statistical analysis of the course of preeclampsia over 10 years
DOI:
https://doi.org/10.15574/PP.2025.4(104).1724Keywords:
pregnancy, hypertensive disorders, preeclampsia, variants of the course of preeclampsia, laboratory parameters, obstetric and perinatal consequences of childbirth, pregnancy complications, fetal growth retardation, premature birth, placental insufficiencyAbstract
Aim - to conduct a retrospective clinical, laboratory and statistical analysis of the course of preeclampsia for 2014-2024 to determine the prevalence of preeclampsia in the population, changes in the frequency and severity of this pregnancy complication over the years, to compare clinical and laboratory indicators to determine the clinical variants of the course of preeclampsia.
Materials and methods. 1379 birth histories with preeclampsia were analyzed: Group I - 1069 pregnant women with moderate preeclampsia and moderate preeclampsia; Group II - 310 pregnant women with severe preeclampsia. The clinical course of the first trimester of pregnancy, gestational age at the time of hospitalization in the maternity ward, general laboratory parameters and clinical symptoms of preeclampsia during the second and third trimesters of pregnancy were studied, namely: hemoglobin level, hematocrit, free bilirubin, platelet count, transaminase level, total protein and fibrinogen level in the blood. Statistical processing of the research results was carried out using standard programs "Microsoft Excel 7.0" and "Statistica 8.0".
Results. Hospitalization dates: up to 26 weeks, 112 (10.5%) pregnant women in Group I were hospitalized against 109 (35.2%) pregnant women in Group II; from 26 to 34 weeks, 394 (36.9%) pregnant women in Group I were hospitalized against 142 (45.8%) pregnant women in Group II; after 34 weeks, 563 (52.6%) pregnant women of Group I were hospitalized compared to 59 (19.0%) pregnant women of Group II; the frequency of premature birth was 121 (39.0%) cases in Group II compared to 203 (18.9%) cases in Group I. In Group II, the following were significantly more frequently observed: hemoconcentration; increased free bilirubin levels (>60 μM/l); thrombocytopenia; increased alanine aminotransferase and aspartate aminotransferase; decreased total blood protein levels (<60 g/l).
Conclusions. A statistical analysis of clinical and laboratory data in pregnant women with preeclampsia over 10 years confirms the presence of two clinical variants of the course of preeclampsia, namely: hemodynamic and cytolytic type.The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of women was obtained for the study.
The author declares that there is no conflict of interest.
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