Rationale and prospects for infusion therapy in women with pre-eclampsia
DOI:
https://doi.org/10.15574/PP.2025.3(103).144147Keywords:
pre-eclampsia, sorbitol, xylitol, low-volume infusion therapyAbstract
Pre-eclampsia is a great obstetric syndrome that occurs in the second half of pregnancy and is related to ischemic placenta syndrome or impaired adaptation of the cardiovascular system of a woman. This disease causes short- and long-term consequences for the health of the mother and fetus. Nowadays, some preventive and therapeutic approaches have been introduced among the contingent of women with high risk and manifested pre-eclampsia.
Aim - to find new effective approaches to the prevention and management of women with pre-eclampsia using low-volume infusion therapy.
It is known that the level of amino sugars in the placentas of women with pre-eclampsia is reduced. Epigenetic studies have shown that women with this pathology have a mutation in the sorbitol dehydrogenase gene. The rationale and prospects for the use of sorbitol- and xylitol-based solutions for low-volume infusion therapy were demonstrated. Emphasis is placed on the possibilities of personalized infusion therapy in pre-eclampsia. It is based on the use of combinations of molecules with a high volemic index and solutions close in composition to blood plasma.
Conclusions. Multifunctional hyperosmolar solutions based on xylitol or sorbitol can be used at any stage of the management of pre-eclamptic patients within the framework of a patient-oriented strategy. The use of xylitol is preferred in the presence of carbohydrate intolerance. Further studies will provide an answer to the issue of the dose, duration, and additional monitoring during infusion therapy with sorbitol and xylitol solutions in women with pre-eclampsia.
The author declares no conflict of interest.
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