Cytokine profile as a marker for predicting the development of infectious and inflammatory diseases in pregnant women with asymptomatic bacteriuria
DOI:
https://doi.org/10.15574/PP.2025.3(103).7581Keywords:
pregnancy, urinary tract infection, asymptomatic bacteriuria, pro- and anti-inflammatory cytokines, prediction of infectious and inflammatory diseases, newbornsAbstract
Aim - to determine the informativeness of the cytokine profile in predicting the development of infectious and inflammatory diseases in the mother and infant in the presence of asymptomatic bacteriuria (АB) in pregnant women.
Materials and methods. A study of the cytokine profile was conducted in 142 pregnant women in the third trimester of pregnancy: I (main) group - 45 patients with АB at a concentration of 105 CFU/ml and more, who received antibacterial therapy (ABT) according to the clinical protocol II group (comparison) - 52 pregnant women with АB at a concentration of 102-104 CFU/ml, who did not receive ABT; control group (CG) - 45 pregnant women without АB. The levels of tumor necrosis factor α (TNFα), interferon γ (IFNγ) and interleukin 4 (IL-4) were studied in peripheral blood and urine.
Results. The average values of TNFα in serum in pregnant women in the CG were significantly lower (to 0.61±0.05 pg/ml) than in pregnant women with АB (in the I group - 42.1±7.59 pg/ml; in the ІI group - 45.19±11.6 pg/ml). The level of IFNγ in the blood serum of pregnant women of the CG was 52.9±12.4 pg/ml. In pregnant women of the II group, a significant decrease in its level to 6.33±0.03 pg/ml was found. In pregnant women of the I group, the level of IFNγ in the blood serum was significantly higher compared to the II group - 35.17±4.5 pg/ml versus 6.33±0.03, but was significantly lower compared to the CG - 52.9±12.4 pg/ml. The level of IL-4 in the blood serum was on average 213.7±56.1 pg/ml in the I group and 139.6±25.2 pg/ml in the II group, which significantly distinguished them from the CG - 98.7±14.9 pg/ml.
Conclusions. In case of АB, pregnant women have a significantly high level of TNFα, IL-4 in blood serum and urine, and a significantly low level of IFNγ in blood serum (p<0.05), which can be considered a marker for predicting the development of infectious and inflammatory diseases in them.
The research was conducted according to principles of Declaration of Helsinki. Protocol of research was proved by local ethical committee, mentioned in institution’s work. An informed sonsennt was collected in order to carry out the research.
Authors declare no conflict of interests.
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