Predicting the success of gestation in women of reproductive age
DOI:
https://doi.org/10.15574/PP.2024.4(100).7075Keywords:
miscarriage, reproductive loss, threat of abortion, first trimester of pregnancy, heat shock proteins, HSP60, GroElAbstract
Miscarriage is a fairly common complication in world medicine. A multidisciplinary approach to the diagnosis and treatment of miscarriage in the first trimester makes it possible to provide timely medical care and predict complications of the neonatal period and perinatal mortality.
Aim - to investigate the level of immunoglobulin G to the proteins HSP60 and GroEL in the blood serum of pregnant women in the first trimester, to conduct a comprehensive analysis of clinical and instrumental examinations of the course of pregnancy, predicting the risks of reproductive loss.
Materials and methods. Materials and methods. The study included 94 pregnant women in the first trimester. Serum sampling for anti-HSP60 and anti-GroEL antibodies was carried out at the first appearance. Pregnant women were divided into two groups. The first group included 33 pregnant women who had no previous pregnancy and childbirth complications at the time of application and in their history. The second group included 61 pregnant women who had a history of habitual miscarriages, the threat of termination of previous pregnancies, pathological childbirth, and at the time of blood donation, there was a threat of termination of pregnancy.
Results. The level of significance of the difference in the comparison groups differed in terms of anamnestic data (woman's age, total number of pregnancies, number of births and abortions). The ultrasound examinations confirmed a statistically significant difference between the groups in terms of fetal biometrics, chorionic location, myometrial structure and the presence of pathological echo inclusions, the state of the appendages and the length of the cervix. A dependence of an increase in anti-GroEL in the blood serum of pregnant women of the first trimester of gestation has been recorded.
Conclusions. The results of the study supported the assumption that the determination of serum levels of heat shock proteins in early pregnancy has diagnostic value and may play a role in determining the success of pregnancy prognosis. Markers of the risk of a complicated pregnancy are the age of the mother, the total number of pregnancies, the number of births and abortions. The risks of a complicated course of pregnancy increase with changes in fetal biometrics, disorders of the structure of the myometrium and chorion, the presence of pathological echo inclusions, and the state of the uterine appendages.
The study was conducted in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent was obtained from the patients for conducting the study.
The authors declare no conflict of interest.
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