Features of pregnancy and childbirth in pregnant women with different vitamin D statuses
DOI:
https://doi.org/10.15574/PP.2024.4(100).5662Keywords:
25(OH)D concentration, vitamin D deficiency, pregnancy, gestational complicationsAbstract
Vitamin D is an essential element for human health, and its deficiency has become a global concern, particularly among pregnant women. According to data, the prevalence of vitamin D deficiency reaches 58% in European countries, while in Ukraine, 81.8% of the population suffers from its deficiency. Vitamin D plays a critical role in pregnancy physiology, and its deficiency is associated with significant obstetric and perinatal complications.
Aim - to determine the vitamin D status of pregnant women and its role in the occurrence of gestational complications.
Materials and methods. The study, conducted at the Perinatal Center in Kyiv, aimed to assess the vitamin D levels in pregnant women and its impact on the development of obstetric complications. A total of 540 pregnant women were examined and divided into groups based on their vitamin D levels.
Results. Vitamin D deficiency was observed in 46.8% of pregnant women, insufficiency in 37.1%, and only 16.1% had optimal levels. Women with deficiency had an average vitamin D level of 15.48±2.69 ng/mL, while those with insufficiency had 24.32±3.68 ng/mL (p<0.05 compared to the deficiency group). Women with vitamin D deficiency more frequently suffered from gastrointestinal and musculoskeletal disorders, with the risk of musculoskeletal pathology being increased by 4.38 times (p<0.05). The study found that vitamin D deficiency significantly raises the risk of preeclampsia (58.1%), preterm birth (50.2%), and fetal growth restriction (32.9%). Women with normal vitamin D levels more often delivered vaginally (57.1%). Cesarean surgeries were more often encountered in women with vitamin D deficiency.
Conclusions. This study highlights the importance of timely diagnosis and correction of vitamin D deficiency in pregnant women to reduce the risk of adverse maternal and neonatal outcomes.
The study was conducted following the principles of the Declaration of Helsinki. The study protocol was approved by the ethics committee of the participating institution. Informed consent was obtained from all patients for the research.
The authors declare no conflict of interest.
References
Abbasalizadeh S, Abam F, Mirghafourvand M, Abbasalizadeh F, Taghavi S, Hajizadeh K. (2020, Nov). Comparing levels of vitamin D, calcium and phosphorus in normotensive pregnant women and pregnant women with preeclampsia. J Obstet Gynaecol. 40(8): 1069-1073. https://doi.org/10.1080/01443615.2019.1678575; PMid:31814492
Alifu X, Si S, Qiu Y, Cheng H, Huang Y, Chi P et al. (2023, Aug 2). The Association of Vitamin D during Pregnancy and mRNA Expression Levels of Inflammatory Factors with Preterm Birth and Prelabor Rupture of Membranes. Nutrients. 15(15): 3423. https://doi.org/10.3390/nu15153423; PMid:37571360 PMCid:PMC10421124
Alzohily B, Al Menhali A, Gariballa S, Munawar N, Yasin J, Shah I. (2024, Mar 30). Unraveling the complex interplay between obesity and vitamin D metabolism. Sci Rep. 14(1): 7583. https://doi.org/10.1038/s41598-024-58154-z; PMid:38555277 PMCid:PMC10981658
Aune D, Schlesinger S, Henriksen T, Saugstad OD, Tonstad S. (2017, Nov). Physical activity and the risk of preterm birth: a systematic review and meta-analysis of epidemiological studies. BJOG. 124(12): 1816-1826. Epub 2017 May 30. https://doi.org/10.1111/1471-0528.14672; PMid:28374930
Barbosa O, Sim-Sim M, Silvestre MP, Pedro C, Cruz D. (2024, Feb 28). Effects of vitamin D levels during pregnancy on prematurity: a systematic review protocol. BMJ Open. 14(2): e076702. https://doi.org/10.1136/bmjopen-2023-076702; PMid:38418231 PMCid:PMC10910675
Cheng H, Chi P, Zhuang Y, Alifu X, Zhou H, Qiu Y et al. (2023, Aug 16). Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study. Nutrients. 15(16): 3593. https://doi.org/10.3390/nu15163593; PMid:37630783 PMCid:PMC10459690
Dahma G, Neamtu R, Nitu R, Gluhovschi A, Bratosin F, Grigoras ML et al. (2022, Jul 22). The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study. Nutrients. 14(15): 3008. https://doi.org/10.3390/nu14153008; PMid:35893862 PMCid:PMC9330723
Da Silveira EA, Moura LANE, Castro MCR, Kac G, Hadler MCCM, Noll PRES et al. (2022, Oct 17). Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis. Nutrients. 14(20): 4351. https://doi.org/10.3390/nu14204351; PMid:36297034 PMCid:PMC9612098
Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M et al. (2024, Jun 3). Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 109(8): 1907-1947. doi: 10.1210/clinem/dgae290. Erratum in: J Clin Endocrinol Metab. 2024 Dec 16:dgae854. https://doi.org/10.1210/clinem/dgae854; PMid:39679956
Farhangnia P, Noormohammadi M, Delbandi AA. (2024, May 2). Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis. Reprod Health. 21(1): 61. https://doi.org/10.1186/s12978-024-01797-y; PMid:38698459 PMCid:PMC11064344
Garand M, Toufiq M, Singh P, Huang SSY, Tomei S, Mathew R et al. (2021, May 10). Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population. Int J Mol Sci. 22(9): 5041. https://doi.org/10.3390/ijms22095041; PMid:34068701 PMCid:PMC8126205
Hu KL, Zhang CX, Chen P, Zhang D, Hunt S. (2022, Feb 27). Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis. Nutrients. 14(5): 999. https://doi.org/10.3390/nu14050999; PMid:35267975 PMCid:PMC8912474
Jamali Z, Ghorbani F, Shafie'ei M, Tolooefar F, Maleki E. (2023, Jun 26). Risk factors associated with vitamin D deficiency in preterm neonates: a single-center step-wise regression analysis. BMC Pediatr. 23(1): 324. https://doi.org/10.1186/s12887-023-04088-w; PMid:37365549 PMCid:PMC10291764
Kelly CB, Wagner CL, Shary JR, Leyva MJ, Yu JY, Jenkins AJ et al. (2020, Jul 10). Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes. Nutrients. 12(7): 2048. https://doi.org/10.3390/nu12072048; PMid:32664257 PMCid:PMC7400952
Lima MS, Pereira M, Castro CT, Santos DB. (2022, Feb 10). Vitamin D deficiency and anemia in pregnant women: a systematic review and meta-analysis. Nutr Rev. 80(3): 428-438. https://doi.org/10.1093/nutrit/nuab114; PMid:34969067
Lin CH, Lin PS, Lee MS, Lin CY, Sung YH, Li ST et al. (2023, Jan 3). Associations between Vitamin D Deficiency and Carbohydrate Intake and Dietary Factors in Taiwanese Pregnant Women. Medicina (Kaunas). 59(1): 107. https://doi.org/10.3390/medicina59010107; PMid:36676731 PMCid:PMC9863845
Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR. (2022, May 1). Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children. Nutrients. 14(9): 1900. https://doi.org/10.3390/nu14091900; PMid:35565867 PMCid:PMC9105305
Moon RJ, Harvey NC, Cooper C, D'Angelo S, Crozier SR, Inskip HM et al. (2016, Dec). Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy. J Clin Endocrinol Metab. 101(12): 5012-5020. Epub 2016 Oct 27. https://doi.org/10.1210/jc.2016-2869; PMid:27788053 PMCid:PMC5155676
Morales-Suárez-Varela M, Uçar N, Soriano JM, Llopis-Morales A, Sanford BS, Grant WB. (2022, Oct 4). Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis. Nutrients. 14(19): 4124. https://doi.org/10.3390/nu14194124; PMid:36235776 PMCid:PMC9572094
Palacios C, Kostiuk LL, Cuthbert A, Weeks J. (2024, Jul 30). Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 7(7): CD008873. https://doi.org/10.1002/14651858.CD008873.pub5; PMid:39077939
Poladich IV, Govsieiev DO. (2024). Peculiarity of vitamin D status in pregnant women. Ukrainian Journal Health of Woman. 4(173): 46-51. https://doi.org/10.15574/HW.2024.4(173).4651
Raia-Barjat T, Sarkis C, Rancon F, Thibaudin L, Gris JC et al. (2021, Oct 20). Vitamin D deficiency during late pregnancy mediates placenta-associated complications. Sci Rep. 11(1): 20708. https://doi.org/10.1038/s41598-021-00250-5; PMid:34671075 PMCid:PMC8528848
Shen Y, Pu L, Si S, Xin X, Mo M, Shao B et al. (2020, May). Vitamin D nutrient status during pregnancy and its influencing factors. Clin Nutr. 39(5): 1432-1439. Epub 2019 Jun 8. https://doi.org/10.1016/j.clnu.2019.06.002; PMid:31229327
Vasdeki D, Tsamos G, Koufakis T, Goulis DG, Asimakopoulos B, Michou V et al. (2023, Dec). "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes. Hormones (Athens). 22(4): 547-562. https://doi.org/10.1007/s42000-023-00486-y; PMid:37698832
Vranić L, Mikolašević I, Milić S. (2019, Aug 28). Vitamin D Deficiency: Consequence or Cause of Obesity? Medicina (Kaunas). 55(9): 541. https://doi.org/10.3390/medicina55090541; PMid:31466220 PMCid:PMC6780345
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