The effect of drug dependence on the level of lipid peroxidation in women with chronic inflammatory diseases of the genital organs caused by sexually transmitted infections




lipid peroxidation, drug addiction, chronic inflammatory diseases of the genital organs, sexually transmitted infections, antioxidant system, medication correction of changes


Oxidative stress, induced by drug addiction, and its consequences for women's reproductive health, especially in the context of chronic inflammatory diseases of the genital organs caused by sexually transmitted infections (STIs), is one of the significant areas of impact.

Aim - to assess the effect of drug addiction on the level of lipid peroxidation (LPO) in women with chronic inflammatory diseases of the genital organs caused by sexually transmitted infections (STIs), which will allow to further determine the ways of correcting the detected changes.

Materials and methods. The study investigated the level of LPO in 60 women with chronic inflammatory diseases of the genital organs caused by sexually transmitted infections and with drug and psychotropic substance dependence. Women were divided into 3 groups depending on the quality of drugs and psychotropic substances they abused: the Group 1 - 25 women addicted to several drugs; the Group 2 - 25 women addicted to opioids; the Group 3 - 10 women addicted to sleeping pills or sedatives.

The intensity of LPO and the state of the antioxidant system were assessed by the spectrophotometric method. Statistical data processing was performed using the “Data Analysis” package in Microsoft Excel.

Results. The study showed that women with drug addiction exhibit increased levels of LPO, indicating a disruption of the antioxidant system and increased formation of free radicals. This can cause damage to cellular membranes and other biomolecules. The use of synthetic opiate receptor antagonist drug in treatment contributed to the normalization of these indicators, pointing to the restoration of the antioxidant system and reducing the risk of further oxidative stress.

Conclusions. Drug dependence causes an increase in oxidative stress in women with STIs, which negatively affects their reproductive health. The synthetic opiate receptor antagonist drug can be effective in reducing the levels of LPO and improving the condition of patients.

The research was conducted according to principles of Declaration of Helsinki. Protocol of research was proved by local ethical committee, mentioned in institution’s work. Informed consent of women was obtained for the study.

No conflict of interests was declared by the authors.


Babor T et al. (2009). Harms associated with illicit drug use, in Drug Policy and the Public Good. Oxford University Press.

Bachi K et al. (2017). Is biological aging accelerated in drug addiction? Curr Opin Behav Sci. 13: 34-39.; PMid:27774503 PMCid:PMC5068223

Beyrer C et al. (2004). Methamphetamine users in northern Thailand: changing demographics and risks for HIV and STD among treatment-seeking substance abusers. International Journal of Std & Aids. 15(10): 697-704.

Haley N et al. (2002). Unsafe sex, substance abuse, and domestic violence: How do recently trained obstetricians-gynecologists fare at lifestyle risk assessment and counseling on STD prevention? Preventive Medicine. 34(6): 632-637.; PMid:12052024

Huba GJ et al. (2000). Predicting substance abuse among youth with, or at high risk for, HIV. Psychology of Addictive Behaviors. 14(2): 197-205.; PMid:10860119

Huestis MA, Choo RE. (2002). Drug abuse's smallest victims: in utero drug exposure. Forensic Science International. 128(1-2): 20-30.; PMid:12208017

Janssen EM et al. (2020). Analysis of Patient Preferences in Lung Cancer - Estimating Acceptable Tradeoffs Between Treatment Benefit and Side Effects. Patient Prefer Adherence. 14: 927-937.; PMid:32581519 PMCid:PMC7276327

Kluwe-Schiavon B et al. (2020). Sensitivity to gains during risky decision-making differentiates chronic cocaine users from stimulant-naïve controls. Behav Brain Res. 379: 112386.; PMid:31778734

Little BB et al. (2003). Treatment of substance abuse during pregnancy and infant outcome. American Journal of Perinatology. 20(5): 255-262.; PMid:13680509

Mayer KH et al. (2012). Ongoing Sexually Transmitted Disease Acquisition and Risk-Taking Behavior Among US HIV-Infected Patients in Primary Care: Implications for Prevention Interventions. Sexually Transmitted Diseases. 39(1): p. 1-7.; PMid:22183836 PMCid:PMC3740591

McGowan JP et al. (2004). Risk behavior for transmission of human immunodeficiency virus (HIV) among HIV-seropositive individuals in an urban setting. Clinical Infectious Diseases. 38(1): 122-127.; PMid:14679457

Panday A et al. (2015). NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol. 12(1): 5-23.; PMid:25263488 PMCid:PMC4654378

Podolskyi VlV, Podolskyi VV. (2017). Perekysne okyslennia lipidiv yak proiav oksydatyvnoho stresu v orhanizmi zhinok iz zminamy reproduktyvnoho zdorov'ia na tli somatoformnykh zakhvoriuvan iz porushenniamy vehetatyvnoho homeostazu. Aktualni pytannia pediatrii, akusherstva ta hinekolohii. 2: 98-104.

Podolskyi VlV, Podolskyi VV. (2017). Modern options of outpatient treatment of chronic inflammatory diseases in fertile aged women caused. Health of woman. 5(121): 132-136.

Podolskyi VlV, Podolskyi VV. (2020). Features of changes in the vaginal microbiota of women of fertile age as a possible mechanism for the occurrence of chronic inflammatory diseases of the genital organs and modern correction possibilities. Health of woman. 2(148): 60-64. doi: 10.15574/HW.2020.148.60.

Podolskyi VV et al. (2017). Peculiarities of microbiocenosis of urogenital organs in women with changes in reproductive health against the background of somatoform diseases and violation of vegetative homeostasis. Materials of the All-Ukrainian scientific and practical conference with international participation "Infection control and antimicrobial resistance in the field of public health and veterinary medicine". 1.06.2017. Kyiv: 57-63.

Sanvicente-Vieira B et al. (2019). Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users. PLoS One. 14(6): e0218334.; PMid:31226126 PMCid:PMC6588218

Volkow ND, Michaelides M, Baler R. (2019). The Neuroscience of Drug Reward and Addiction. Physiol Rev. 99(4): 2115-2140.; PMid:31507244 PMCid:PMC6890985

Womersley JS et al. (2019). Targeting redox regulation to treat substance use disorder using N‐acetylcysteine. Eur J Neurosci. 50(3): 2538-2551.; PMid:30144182 PMCid:PMC6387857

Woods WJ et al. (2000). HIV infection and risk behaviors in two cross-sectional surveys of heterosexuals in alcoholism treatment. Journal of Studies on Alcohol. 61(2): 262-266.; PMid:10757137

Wu LT et al. (2009). Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: A national study. Public Health. 123(8): 557-564.; PMid:19656538 PMCid:PMC2757289

Zhang Y et al. (2011). Redox control of the survival of healthy and diseased cells. Antioxid Redox Signal. 15(11): 2867-908.; PMid:21457107