Clinical observation of teratoma of the brain of a newborn




teratoma of the newborn brain, congenital tumors, central nervous system


A congenital brain tumor is a tumor detected before birth or during the first two months of life. The frequency of congenital brain tumors is extremely low - 0.34 per 1 million newborns, and no more than 1.5% of all neoplasms of the central nervous system in children, but the rapid growth of the tumor and the destruction of normal brain tissue give them a fatal prognosis.

Purpose - to expand knowledge on the possibilities of antenatal diagnosis and the features of the management of the early neonatal period of congenital mіalformations based on the clinical observation of fetal brain teratoma.

An overview of literature sources is provided on the prevalence of pathology, histological structure (teratomas, neuroepithelial and mesenchymal tumors), features of the clinical course that distinguish them from childhood tumors - mainly supratentorial localization, lack of growth restriction due to the mobility of the bones of the skull, prognosis and tactics of pregnancy and childbirth . Ultrasound examination is the main method of diagnosis of brain tumors, which are visualized in the form of a solid or cystic calcified formation or not, and manifestations of hypervascularization can also be absent or present. The features of the structure and development of the teratoma, which contains cells of all 3 germ layers and has properties of rapid destructive growth, are also described. Hydrocephalus accompanying congenital brain tumors can be caused both by compression of the ventricular system and intracranial hemorrhages. Thanks to modern diagnostic capabilities, most cases are detected in terms of possible termination of pregnancy, in the case of childbirth with such a pathology, in 60% of cases, a cesarean section is used.

The given clinical case shows the possibilities of antenatal diagnosis of a brain tumor and even clearly establishing the depth of the lesion, at the same time as the lack of treatment options.

The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.

No conflict of interests was declared by the authors.

Author Biography

V.V. Bila, KNP «Perinatal Center of Kyiv»

Institute of Postgraduate Education of Bogоmolets National Medical University, Kyiv, Ukraine


Arisoy R, Erdogdu E, Kumru P et al. (2016). Prenatal diagnosis and outcomes of fetal teratomas: fetal Teratoma. J Clin Ultrasound. 44(2): 118-125.; PMid:26426797

Cavalheiro S, Moron AF, Hisaba W, Dastoli P, Silva NS. (2003). Fetal brain tumors. Childs Nerv Syst. 19: 529-536.; PMid:12908112

Cornejo P, Feygin T, Vaughn J. (2020). Imaging of fetal brain tumors. Pediatr Radiol. 50: 1959-1973.; PMid:33252762

Court WM, Doll R, Hill RB. (1960). Incidence of leukaemia after exposure to diagnostic radiation in utero. Br Med J. 2: 1539-1545.; PMid:13695977 PMCid:PMC2098397

Hoff NR, Mackay IM. (1980). Prenatal ultrasound diagnosis of intracranial teratoma. J Clin Ultrasound. 8: 247-249.; PMid:6769967

Isaacs HII. (2002). Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 27: 333-342.; PMid:12504200

Meizner I. (2012). Tumors of the Brain. In: Ultrasonography of the prenatal brain., editor. 3rd ed. McGrawHill. New York: 393-406.

Milani HJ, Araujo JE, Cavalheiro S, Oliveira PS, Hisaba WJ, Barreto EQ et al. (2015). Fetal brain tumors: Prenatal diagnosis by ultrasound and magnetic resonance imaging. World J Radiol. 28; 7(1): 17-21.; PMid:25628801 PMCid:PMC4295174

Peiro JL, Crombleholme TM. (2019). Error traps in fetal surgery. Semin Pediatr Surg. 28(3): 143-150.; PMid:31171149

Simonini C, Strizek B, Berg C, Gembruch U, Mueller A, Heydweiller A, Geipel A. (2020). Fetal teratomas - A retrospective observational single-center study. Prenatal diagnosis. 4(3): 301-307.; PMid:33242216