Clinical observation of teratoma of the brain of a newborn
DOI:
https://doi.org/10.15574/PP.2023.96.136Keywords:
teratoma of the newborn brain, congenital tumors, central nervous systemAbstract
A congenital brain tumor is a tumor detected before birth or during the first two months of life. The frequency of congenital brain tumors is extremely low - 0.34 per 1 million newborns, and no more than 1.5% of all neoplasms of the central nervous system in children, but the rapid growth of the tumor and the destruction of normal brain tissue give them a fatal prognosis.
Purpose - to expand knowledge on the possibilities of antenatal diagnosis and the features of the management of the early neonatal period of congenital mіalformations based on the clinical observation of fetal brain teratoma.
An overview of literature sources is provided on the prevalence of pathology, histological structure (teratomas, neuroepithelial and mesenchymal tumors), features of the clinical course that distinguish them from childhood tumors - mainly supratentorial localization, lack of growth restriction due to the mobility of the bones of the skull, prognosis and tactics of pregnancy and childbirth . Ultrasound examination is the main method of diagnosis of brain tumors, which are visualized in the form of a solid or cystic calcified formation or not, and manifestations of hypervascularization can also be absent or present. The features of the structure and development of the teratoma, which contains cells of all 3 germ layers and has properties of rapid destructive growth, are also described. Hydrocephalus accompanying congenital brain tumors can be caused both by compression of the ventricular system and intracranial hemorrhages. Thanks to modern diagnostic capabilities, most cases are detected in terms of possible termination of pregnancy, in the case of childbirth with such a pathology, in 60% of cases, a cesarean section is used.
The given clinical case shows the possibilities of antenatal diagnosis of a brain tumor and even clearly establishing the depth of the lesion, at the same time as the lack of treatment options.
The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
References
Arisoy R, Erdogdu E, Kumru P et al. (2016). Prenatal diagnosis and outcomes of fetal teratomas: fetal Teratoma. J Clin Ultrasound. 44(2): 118-125. https://doi.org/10.1002/jcu.22310; PMid:26426797
Cavalheiro S, Moron AF, Hisaba W, Dastoli P, Silva NS. (2003). Fetal brain tumors. Childs Nerv Syst. 19: 529-536. https://doi.org/10.1007/s00381-003-0770-9; PMid:12908112
Cornejo P, Feygin T, Vaughn J. (2020). Imaging of fetal brain tumors. Pediatr Radiol. 50: 1959-1973. https://doi.org/10.1007/s00247-020-04777-z; PMid:33252762
Court WM, Doll R, Hill RB. (1960). Incidence of leukaemia after exposure to diagnostic radiation in utero. Br Med J. 2: 1539-1545. https://doi.org/10.1136/bmj.2.5212.1539; PMid:13695977 PMCid:PMC2098397
Hoff NR, Mackay IM. (1980). Prenatal ultrasound diagnosis of intracranial teratoma. J Clin Ultrasound. 8: 247-249. https://doi.org/10.1002/jcu.1870080313; PMid:6769967
Isaacs HII. (2002). Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 27: 333-342. https://doi.org/10.1016/S0887-8994(02)00459-9; PMid:12504200
Meizner I. (2012). Tumors of the Brain. In: Ultrasonography of the prenatal brain., editor. 3rd ed. McGrawHill. New York: 393-406.
Milani HJ, Araujo JE, Cavalheiro S, Oliveira PS, Hisaba WJ, Barreto EQ et al. (2015). Fetal brain tumors: Prenatal diagnosis by ultrasound and magnetic resonance imaging. World J Radiol. 28; 7(1): 17-21. https://doi.org/10.4329/wjr.v7.i1.17; PMid:25628801 PMCid:PMC4295174
Peiro JL, Crombleholme TM. (2019). Error traps in fetal surgery. Semin Pediatr Surg. 28(3): 143-150. https://doi.org/10.1053/j.sempedsurg.2019.04.012; PMid:31171149
Simonini C, Strizek B, Berg C, Gembruch U, Mueller A, Heydweiller A, Geipel A. (2020). Fetal teratomas - A retrospective observational single-center study. Prenatal diagnosis. 4(3): 301-307. https://doi.org/10.1002/pd.5872; PMid:33242216
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Ukrainian Journal of Perinatology and Pediatrics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal “Ukrainian Journal of Perinatology and Pediatrics” is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license(СС BY-NC).
Authors transfer the copyright to the Journal “MODERN PEDIATRICS. UKRAINE” when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.
