Influence of psychoactive substance use and sexually transmitted infections on the cervical cytology
DOI:
https://doi.org/10.15574/PP.2023.96.32Keywords:
psychoactive substance abuse, sexually transmitted infections, cervical health, cytological analysis, squamous cell abnormalities, koilocytosis, low-grade squamous intraepithelial lesion, cervical dysplasia, cervical cancer screening, women’s health, public health initiatives, preventive healthcare, профілактична медицинаAbstract
The introduction addresses the societal stigma surrounding psychoactive substance abuse and its implications for women’s health, particularly concerning cervical health. It sets the context for the study by highlighting the need to understand the impact of substance abuse and sexually transmitted infections (STIs) on cervical health.
Purpose - to investigate the effects of psychoactive substance abuse and concurrent STIs on the health of the cervix in women. The study seeks to identify correlations between substance abuse, STIs, and cervical pathologies, providing valuable insights for healthcare strategies.
Materials and methods. The study involved a sample of 160 women divided into groups based on their use of psychoactive substances and the presence of STIs. Cervical cytological smears were collected and analysed using Romanowsky-Giemsa and Papanicolaou staining methods. This approach aimed to detect and categorize any cellular abnormalities in the cervical epithelium.
Results. The findings revealed a significant correlation between the abuse of psychoactive substances and the frequency of squamous cell abnormalities in the cervix, especially in those with concurrent STIs. Conditions like koilocytosis and low-grade squamous intraepithelial lesions (LSIL) were notably prevalent among substance abusers, indicating an increased risk for cervical dysplasia and potential progression to cervical cancer.
Conclusions. The study concludes that psychoactive substance abuse, particularly in combination with STIs, significantly increases the risk of cervical pathologies in women. This underscores the necessity for enhanced cervical cancer screening and prevention strategies targeted at women who abuse psychoactive substances. The findings highlight the importance of addressing substance abuse and STIs in women’s health programs and public health initiatives, especially in high-risk groups.
The study protocol was approved by the Local ethics committees of the institutions mentioned in the paper. An informed parental consent was obtained for the study in women.
No conflict of interests was declared by the authors.
References
Abebe M, Eshetie S, Tessema B. (2021). Prevalence of sexually transmitted infections among cervical cancer suspected women at University of Gondar Comprehensive Specialized Hospital, North-west Ethiopia. BMC Infect. Dis. 21: 378. https://doi.org/10.1186/s12879-021-06074-y; PMid:33888090 PMCid:PMC8063310
Abudoukadeer A, Niyazi M, Aikula A, Kamilijian M, Sulaiman X, Mutailipu A et al. (2015). Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women. Eur. J. Gynaecol. Oncol. 36: 546-550.
Ackermann S, Renner S, Fasching P, Poehls U, Bender H, Beckmann M. (2005). Awareness of general and personal risk factors for uterine cancer among healthy women. Eur. J. Cancer Prev. 14: 519-524. https://doi.org/10.1097/00008469-200512000-00005; PMid:16284496
Arbyn M, Simon M, de Sanjosé S, Clarke M, Poljak P, Rezhake R et al. (2022). Accuracy and effectiveness of HPV mRNA testing in cervical cancer screening: A systematic review and meta-analysis. Lancet Oncol. 23: 950-960. https://doi.org/10.1016/S1470-2045(22)00294-7; PMid:35709810
Arbyn M, Verdoodt F, Snijders P, Verhoef V, Suonio E, Dillner L et al. (2014). Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: A meta-analysis. Lancet Oncol. 15: 172-183. https://doi.org/10.1016/S1470-2045(13)70570-9; PMid:24433684
Arrossi S, Ramos S, Straw C, Thouyaret L, Orellana L. (2016). HPV testing: A mixed-method approach to understand why women prefer self-collection in a middle-income country. BMC Public Health. 16: 832. https://doi.org/10.1186/s12889-016-3474-2; PMid:27538390 PMCid:PMC4990977
Bennett K, Waller J, Chorley A, Ferrer R, Haddrell J, Marlow L. (2018). Barriers to cervical screening and interest in self-sampling among women who actively decline screening. J. Med. Screen. 25: 211-217. https://doi.org/10.1177/0969141318767471; PMid:29649936 PMCid:PMC6262593
Carlson LM, Gonzalez S. (2014). Knowledge of cervical cancer pathology of high school students in San Carlos, Costa Rica. Rev Biol Trop. 62(3): 877-886. https://doi.org/10.15517/rbt.v62i3.14063; PMid:25412520
Choi S, Ismail A, Pappas-Gogos G, Boussios S. (2023). HPV and cervical cancer: A review of epidemiology and screening uptake in the UK. Pathogens. 12: 298. https://doi.org/10.3390/pathogens12020298; PMid:36839570 PMCid:PMC9960303
Dau H, Trawin J, Nakisige C, Payne B, Vidler M, Singer J et al. (2023). The social and economic impacts of cervical cancer on women and children in low- and middle-income countries: A systematic review. Int. J. Gynaecol. Obstet. 160: 751-761. https://doi.org/10.1002/ijgo.14395; PMid:35962711
Diclemente R, Wingood G, Sionean C, Crosby R, Harrington K, Davies S et al. (2002). Association of adolescents' history of sexually transmitted disease (STD) and their current high-risk behavior and STD status. Sex Transm Dis. 29(9): 503-509. https://doi.org/10.1097/00007435-200209000-00002; PMid:12218840
Dinh T, Centers K, Control D, Diseases C. (2013). Integration of preventing mother-to-child transmission of HIV and syphilis testing and treatment in antenatal Care Services in the Northern Cape and Gauteng Provinces, South Africa. Sex Transm Dis. 40(11): 846-851. https://doi.org/10.1097/OLQ.0000000000000042; PMid:24113405 PMCid:PMC6823923
Ghadicolaee S, Pazhoohan M, Hasanzadeh A, Nematolahi M, Yahyapour Y, Ranaee M et al. (2021). Low frequency of human cytomegalovirus in cancerous and precancerous cervical samples of Iranian women. Future Virol. 16: 399-405. https://doi.org/10.2217/fvl-2020-0266
Harper D, DeMars L. (2017). HPV vaccines - a review of the first decade. Gynecol. Oncol. 146: 196-204. https://doi.org/10.1016/j.ygyno.2017.04.004; PMid:28442134
Smith JS, Herrero R, Bosetti C, Muñoz N, Bosch FX, Eluf-Neto J et al. (2002). Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst. 94(21): 1604-1613. https://doi.org/10.1093/jnci/94.21.1604; PMid:12419786
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Ukrainian Journal of Perinatology and Pediatrics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal “Ukrainian Journal of Perinatology and Pediatrics” is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license(СС BY-NC).
Authors transfer the copyright to the Journal “MODERN PEDIATRICS. UKRAINE” when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.
