Influence of complex treatment of periodontal tissue diseases on the indices of antioxidant and prooxidant systems in teenagers and young adults
DOI:
https://doi.org/10.15574/PP.2023.94.113Keywords:
teenagers, young adults, antioxidant defense system, lipid peroxidation, oral fluid, smoking, periodontal tissue diseases, complex treatmentAbstract
Purpose - to study the effect of complex treatment of periodontal tissue diseases on the indices of antioxidant and prooxidant systems of oral fluid in adolescents and young adults.
Materials and methods. The biochemical parameters of oral fluid before and after treatment were studied in 114 adolescents and young adults (15 to 24 years old), who were divided into groups: the Group I included 26 people who smoked traditional cigarettes; the Group II - 22 people who smoked electronic cigarettes (vapes); the Group III - 23 people who smoked tobacco heating devices (IQOS); the Group IV - 43 people without a smoking habit. The following biochemical parameters were studied: the activity of superoxide dismutase and catalase enzymes, dyne conjugates and products that react to thiobarbituric acid, before and after treatment with the proposed complex: general - Quertin, Supervit and BioGaya ProDentis; topical - Stomolik and Holisal and conventional treatment.
Results. In the Group I patients, the activity of superoxide dismutase in the oral fluid decreased by 1.4 times compared to the Group IV patients (p<0.05); in the Group II and III patients - by 1.2 times compared to non-smokers (p<0.05). In the Group I, the activity of the catalase enzyme decreased significantly (2.6 times) compared to the Group IV (p<0.05); in the Group II and III - by 1.8 times compared to non-smokers (p<0.05). The analysis of the data showed that in the Group I, the number of products reacting to thiobarbituric acid increased 2.5 times compared to the Group IV (p<0.05); in the Groups II and III - 1.9 times compared to the Group IV (p<0.05). The amount of diene conjugates in the oral fluid increased in both the Group I and Groups II and III patients, respectively, by 1.4 and 1.2 times compared with the Group IV patients (p<0.05). After treatment, there was an increase in antioxidant defense and inhibition of lipid peroxidation in oral fluid, with better results in the subgroups in which the proposed complex treatment was used, as well as in adolescents and young adults without smoking habits.
Conclusions. In teenagers and young adults smokers, there is an increase in lipid peroxidation and a decrease in the antioxidant properties of oral fluid. Comparison of the results of biochemical parameters before and after treatment of periodontal tissue diseases in the observation groups by different methods indicates the advantages of the proposed complex treatment and allows us to conclude that it is highly effective.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the author.
References
Belenichev IF, Levitskyi EL, Gubskyi YuI, Kovalenko SI, Marchenko OM. (2002). Antioxidant defense system of the body (review). Modern problems of toxicology. 3: 8-19.
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. (2012, Jan). Oxidative stress and antioxidant defense. World Allergy Organ J. 5 (1): 9-19. https://doi.org/10.1097/WOX.0b013e3182439613; PMid:23268465 PMCid:PMC3488923
Druzhina MO, Demina EA, Makovetskaya L. (2019). Oxidative stress metabolites as predictors of radiation and carcinogenic risks. Oncology. 2 (21): 170-175. https://doi.org/10.32471/oncology.2663-7928.t-21-2-2019-g.7457
Hlushchenko TA. (2022). Clinical assessment of the effectiveness of complex treatment of generalized periodontitis in patients with metabolic syndrome. Actual problems of modern medicine. 22; 1 (77): 72-76. https://doi.org/10.31718/2077-1096.22.1.72
Homenko LO, Bidenko NV, Ostapko OL, Golubeva IM. (2016). Pediatric periodontology: the state of problems in the world and in Ukraine. Dentistry news. 3 (88): 67-71.
Homenko LO. (2015). Therapeutic dentistry for children. Vol 2: 328.
Kaskova LF, Honcharenko VA. (2020). The effect of the treatment-prophylactic complex on indicators of lipid peroxidation and antioxidant protection of the oral fluid of children with chronic catarrhal gingivitis. Clinical dentistry. 4: 93-100.
Kinane DF, Stathopoulou PG, Papapanou PN. (2017, Jun 22). Periodontal diseases. Nat Rev Dis Primers. 3: 17038. https://doi.org/10.1038/nrdp.2017.38; PMid:28805207
Kolesnikova OV, Radchenko AO. (2020). A modern view of the mechanisms of the development of oxidative stress and its biomarkers in the most common non-infectious diseases. Ukrainian therapeutic journal. 1: 51-61.
Krinicka IY. (2013). Functional state of the blood antioxidant defence system in rats with modelled hepatopulmonary syndrome. Medical chemistry. 1 (15): 34-39.
Lisetska IS, Rozhko MM. (2023). Biochemical parameters of oral fluid as markers for assessing the state of antioxidant and prooxidant systems in adolescent and young adult smokers. Ukrainian Journal of Perinatology and Pediatrics. 1 (93): 51-57. https://doi.org/10.15574/PP.2023.93.51
Lisetska IS. (2022). The condition of periodontal tissues in adolescents and young adults who smoke. Modern pediatrics. Ukraine. 3 (123): 33-37. https://doi.org/10.15574/SP.2022.123.33
Maliy DU, Antonenko MJ. (2013). Epidemiology of periodontal disease: age aspect. Ukrainian Scientific Medical Youth Journal. 3: 41-43.
Netyukhailo LG, Kharchenko SV. (2014). Active forms of oxygen (literature review). Young scientist. 9 (12): 131-135.
Palasyuk BO, Palasyuk OI. (2012). Peroxidation of lipids and oxidative modification of proteins in oral fluid in middle school children with chronic catarrhal gingivitis. Actual problems of modern medicine: Bulletin of the Ukrainian Medical Stomatological Academy. 4 (40); 12: 50-54.
San Miguel SM, Opperman LA, Allen EP, Svoboda KK. (2011, Jan-Feb). Reactive oxygen species and antioxidant defense mechanisms in the oral cavity: a literature review. Compend Contin Educ Dent. 32 (1): E10-15. PMID: 23738797.
Shcherba VV, Lavrin OY. (2016). Smoking: prevalence and effects on organs and tissues of the oral cavity (literature review). Clinical dentistry. 2: 27-33.
Trochymovych AA, Kishko MM, Slyvka YaI, Ganych OT. (2011). Free radical oxidation and antioxidant system in cardiovascular pathology. Scientific Bulletin of Uzhgorod University, Medicine series. 2 (41): 361-364.
Tyazhka OV, Zagorodnya YM. (2016). State and especially the functioning of lipid peroxidation and antioxidant blood of children of different age. Perinatologiya i pediatriya. 2 (66): 101-105. https://doi.org/10.15574/PP.2016.66.101
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