Risk factors for the development of complicated oligomenorrhea in adolescent girls
DOI:
https://doi.org/10.15574/PP.2022.91.29Keywords:
the course of oligomenorrhea, puberty, lipid profile, carbohydrate profile, vitamin D, prognosisAbstract
The purpose - to identify significant prognostic criteria for the development of a complicated course of oligomenorrhea.
Materials and methods. A clinical and hormonal examination of 64 adolescent girls with oligomenorrhea aged 12-18 was carried out. The following were determined: physical with determination of body mass index, sexual development, parameters of the hormonal background, vitamin D status, lipid spectrum and the state of carbohydrate metabolism.
Results. The most informative sings regarding the formation of metabolic complications of the course of oligomenorrhea were selected by determining the informative clinical and anamnestic signs, hormonal indicators and the status of vitamin D. The following clinical parameters, which may indicate a complicated course of oligomenorrhea with disturbances in carbohydrate metabolism, had the greatest overall informativeness: macrosomia at birth; the mother’s age is more than 35 years at the time of our patient’s birth; in a girl, the age of menarche is up to 11 years, the presence of comorbid pathology (especially cardiovascular disorders) and body weight deficiency. The greatest prognostic significance from the hormonal parameters had high levels of luteinizing hormone, testosterone, total cholesterol, and low estradiol. The clinical, anamnestic and hormonal indicators that may indicate the formation of complications from lipid spectrum disorders were found. It was: deviation of the body weight at birth in both sides, high serum levels of prolactin, cortisol, normative follicle-stimulating hormone, and a moderate decrease in the level of vitamin D.
Conclusions. Significant risk factors for the formation of metabolic complications in girls with oligomenorrhea have been identified. Using them makes it possible to timely determine the prognosis of the course of oligomenorrhea in the majority of patients already at the early stages of the formation of this pathology, to decide on therapy and the implementation of therapeutic and preventive measures in the future.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the SI «Institute of Health Care of Children and Adolescents of the NAMS of Ukraine». The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
References
Arum VRS, Yuniastuti A, Kasimi OW. (2019). The Relationship of Nutritional Status, Physical Activity, Stress, and Menarche to Menstrual Disorder (Oligomenorrhea). Public Health Perspective Journal. URL: https://journal.unnes.ac.id/nju/index.php/phpj/article/view/18410.
Aydin Y, Hassa H, Burkankulu D, Arslantas D, Sayiner D, Ozerdogan N. (2015). What is the Risk of Metabolic Syndrome in Adolescents with Normal BMI who have Polycystic Ovary Syndrome? J Pediatr Adolesc Gynecol. 28 (4): 271-274. https://doi.org/10.1016/j.jpag.2014.08.011; PMid:26049937
Binder AM, Corvalan C, Mericq V et al. (2018). Faster ticking rate of the epigenetic clock is doi associated with faster pubertal development in girls. Epigenetics. 13 (1): 85-94. https://doi.org/10.1080/15592294.2017.1414127; PMid:29235933 PMCid:PMC5836971
Cohn JS, McNamara JR, Schaefer EJ. (1988). Lipoprotein cholesterol concentrations in the plasma of human subjects as measured in the fed and fasted states. Clinical Chemistry. 34 (12): 2456-2459. https://doi.org/10.1093/clinchem/34.12.2456; PMid:3197284
Dong C, Hu X, Tripathi AS. (2022). A brief review of vitamin D as a potential target for the regulation of blood glucose and inflammation in diabetes-associated periodontitis. Mol Cell Biochem. 477 (9): 1-12. https://doi.org/10.1007/s11010-022-04445-w; PMid:35478388
Garbossa SG, Folli F. (2017). Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism. Rev Endocr Metab Disord. 18 (2): 243-258. https://doi.org/10.1007/s11154-017-9423-2; PMid:28409320
Glueck CJ, Woo JG, Khoury PR, Morrison JA, Daniels SR, Wang P. (2015). Adolescent oligomenorrhea (age 14-19) tracks into the third decade of life (age 20-28) and predicts increased cardiovascular risk factors and metabolic syndrome. Metabolism. 64 (4): 539-553. https://doi.org/10.1016/j.metabol.2015.01.005; PMid:25633270
Gu P et al. (2022). Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study. МedRxiv. https://doi.org/10.1101/2022.04.12.22273773
He Y, Zheng D, Shang W, Wang X, Zhao S, Wei Z, Song X, Shi X, Zhu Y, Wang S, Li R, Qiao J. (2020). Prevalence of oligomenorrhea among women of childbearing age in China: A large community-based study. Womens Health (Lond). 16: 1745506520928617. https://doi.org/10.1177/1745506520928617; PMid:32894698 PMCid:PMC7479865
Klimov AN, Nikulycheva NG. (1999). Lipid and lipoprotein metabolism and ego disorders. Saint Petersburg: 512.
Kostopoulou E, Anagnostis P, Bosdou JK, Spiliotis BE, Goulis DG. (2020). Polycystic ovary Syndrome in Adolescents: Pitfalls in Diagnosis and Management. Curr Obes Rep. 9 (3): 193-203. https://doi.org/10.1007/s13679-020-00388-9; PMid:32504286
Kovalyshyn OA. (2020). Clinical aspects in women with menstrual dysfunction in puberty. World Science. 9: 61. https://doi.org/10.31435/rsglobal_ws/30122020/7336
Mulesa O, Snytiuk V, Herzanych S. (2020). Metod nechitkoi klasyfikatsii na osnovi poslidovnoho analizu Valda. Automation of Technological and Business Processes. 11 (4): 35-42. https://doi.org/10.15673/atbp.v11i4.1597
Ongsupharn S, Pantasri T, Lattiwongsakorn W, Morakote N. (2018). The Association between Oligomenorrhea, Onset of Menopause and Metabolic Syndrome in Thai Postmenopausal Women. J Menopausal Med. 2: 100-107. https://doi.org/10.6118/jmm.2018.24.2.100; PMid:30202759 PMCid:PMC6127020
Rajiwade SR, Sagili H, Soundravally R et al. (2018). Endocrine Abnormalities in Adolescents with Menstrual Disorders. J Obstet Gynecol India. 68: 58-64. https://doi.org/10.1007/s13224-017-1035-y; PMid:29391677 PMCid:PMC5783900
Riaz Y, Parekh U. (2021). Oligomenorrhea. StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560575/.
Roa J, Barroso A, Ruiz-Pino F et al. (2018). Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling. Proc Natl Acad Sci USA. 115 (45): E10758-E10767. https://doi.org/10.1073/pnas.1802053115; PMid:30348767 PMCid:PMC6233121
Sadeghi R, Eidi MR, Zamani N. (2018). Аssociation of Serum Vitamin D level and Serum lipids Profile. International Journal of Cardiovascular Practice. 3 (2): 30-33. https://doi.org/10.21859/ijcp-03203
Shapovalova TV, Shaketova ASh. (2020). Profilaktika raka molochnoy zhelezy. Aktualnyie nauchnyie issledovaniya v sovremennom mire. 9-5 (65): 113-116.
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