Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case

Authors

  • O.H. Shadrin SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0002-5901-7013
  • A.P. Volokha Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Ukraine https://orcid.org/0000-0003-3092-2228
  • N.H. Chumachenko SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ukraine
  • V.M. Fysun SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ukraine
  • V.V. Zaiets SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ukraine
  • V.V. Zaiets SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.15574/PP.2020.84.48

Keywords:

infants, congenital cytomegalovirus infection, ganciclovir, valganciclovir, clinical case

Abstract

Cytomegalovirus infection (CMV) is one of the most common causes of fetal infection. Recently fetal infections cause from 11% to 45% of perinatal losses, according to various authors, and are considered to be one of the most likely causes of congenital malformations, which lead to infants disability and reduce quality of life. CMV-infection clinical picture is very diverse, disguised as other diseases. There may be clinical manifestations of both generalized infection and single organ damage, because the virus has tropism to various organs and tissues. Timely diagnosis and treatment are the key to successful therapy of even severe manifestations of congenital CMV-infection in infants. Antiviral drugs usage can be sufficiently justified in patients with severe infection and can prevent complications.

A clinical case of a manifest form of cytomegalovirus infection with severe hepatitis in an infant is presented and the therapeutic efficacy and safety of the ganciclovir and valganciclovir antiviral drugs are shown. The study is performed in accordance with principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the article. Informed consent of parents was obtained for the research. The authors declare no conflict of interest.

References

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Published

2020-12-30

Issue

No. 4(84) (2020): Ukrainian journal of Perinatology and Pediatrics

Section

Clinical case

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