History of breasts during pregnancy in women with a history of endocrine and inflammatory infertility

Abstract

A significant increase in the incidence of mammary pathology to 70.0% and 83.3%, respectively, in women with endocrine and combined infertility in history is explained by the presence of factors of the development of mastopathies, namely: age, burdened gynecological history (endocrine and combined, infertile, increased frequency of somatic pathology (metabolic syndrome, obesity, insulin resistance), complicated course of pregnancy.
Purpose — to study the history of mammary glands during pregnancy in women with a history of endocrine and inflammatory infertility.
Patients and methods. We examined breasts during pregnancy in 160 women. The distribution of pregnant women into groups is based on the factor of infertility: group I — 50 pregnant women who had a history of endocrine infertility, group II — 50 pregnant women who had a history of infertility of inflammatory genesis, group III — 30 pregnant women who had a history of combined infertility endocrine, control group — 30 healthy pregnant women without history of infertility. All women underwent palpation and ultrasound examination of the mammary glands during pregnancy.
Results. In the control group with ultrasound examination and palpation of the mammary glands, only 4 (13.3%) pregnant women without infertility revealed a history of mammary gland pathology, of these in 2 pregnant women (6.7%) of the first group we found fibrocystic mastopathy with the predominance of the fibrotic component, breast fibroadenoma was 1 (3.3%), and 1 (3.3%) had signs of fibrocystic mastopathy with a predominance of the cystic component. In ultrasound examination and palpation of mammary glands, 35 (70.0%) pregnant women with a history of endocrine infertility (group I) found a pathology of mammary glands, of these, in 18 pregnant women (36.0%) of the first group, we found fibrocystic mastopathy with predominance fibrous component, in 5 (10.0%) patients revealed breast fibroadenoma, and in 12 (24.0%) signs of fibrocystic mastopathy with a predominance of cystic component. In the second group, ultrasound examination and palpation of mammary glands in 12 (24.0%) pregnant women with inflammatory infertility revealed a history of mammary gland pathology, of which in 5 pregnant women (10.0%) of the first group we found fibrocystic mastopathy with a predominance of fibrous component, in 2 (4.0%) patients revealed breast fibroadenoma, and in 5 (10.0%) signs of fibrocystic mastopathy with a predominance of the cystic component. At ultrasound examination and palpation of mammary glands in 25 (83.3%) pregnant women of group III with combined infertility in the anamnesis revealed pathology of mammary glands, of them in 10 pregnant women (33.3%) of the first group we found fibrocystic mastopathy with the predominance of the fibrous component, in 5 (16.6%) patients revealed breast fibroadenoma, and in 10 (33.3%) signs of fibrocystic mastopathy with a predominance of the cystic component.
Conclusions. In 13.3% of healthy pregnant women with ultrasound examination and palpation of the mammary glands revealed a pathology of the mammary glands. Pregnant women with inflammatory infertility had a history of breast cancer (II) in 24.0% of patients. In women with a history of endocrine (I) and combined (III) infertility, there was a significant increase in mammary pathology (70.0% and 83.3%, respectively).
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of Kyiv City Children's Clinical Hospital No. 1. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest were declared by the authors.